S. C. Freed
Jan 1, 1967
Citations
1
Influential Citations
2
Citations
Journal
Proceedings of the Society for Experimental Biology and Medicine
Abstract
Summary Acetoxycycloheximide, an inhibitor of protein synthesis at the ribosomes, reduces the blood pressure of normotensive and hypertensive rats. Chloramphenicol, which has a similar but not identical action, also reduces blood pressure of hypertensive rats. The degree of blood pressure depression to both substances is dose-dependent and is appreciable in non-toxic amounts. Puromycin, which inhibits ribosomal synthesis of protein, but through release of rather than suppression of polypeytides, fails to reduce blood pressures at much higher dosage levels relative to toxicity. Blood pressure depression following acetoxycycloheximide or chlor-amphenicol administration is corrected by prednisolone. Rats treated with acetoxycycloheximide respond to 1-norepinephrine with normally vigorous blood pressure elevation suggesting that phasic contractile proteins remain intact.