V. Belova, E. Barnová, K. Barna
Oct 15, 1975
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Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The effect of rolitetracycline (N-pyrolidin-methyl-tetracycline) on the consumption of O2 and Pi by heart muscle mitochondria on the glycolytic activity of heart muscle homogenates, on the glycogen concentration in the heart muscle and glycaemia in rabbits after administration of 20 mg/kg body wt daily for 6 or 12 days was studied. No significant changes were found in any of the parameters after 6 days of treatment. Treatment for 12 days resulted in hypoxia, increased consumption of inorganic phosphate, increased glycaemia, increased glycolytic activity due to hypoxia and decreased glycogen concentration in the heart muscle.