J. J. Aleo
Aug 1, 1974
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
The effect of sodium salicylate on the metabolism of 3T6 fibroblasts treated with the lathyrogen β-aminopropionitrile was studied. A 5 mM concentration of the lathyrogen and/or 0.5 mM sodium salicylate was used to study proliferation, collagen synthesis, and mucopolysaccharide synthesis as measured by 35SO4 incorporation. Sodium salicylate was able to reverse all lathyrogen-mediated changes to control or near control values. The diversity of these biosynthetic activities suggests that the influence of sodium salicylate on lathyrogen-treated cells is a result of a general metabolic effect rather than a specific one; the exact mechanism of action remains unknown.