M. Tuck, D. W. Chandler, Daryl M. Mayes
Nov 1, 1977
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0
Influential Citations
29
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Quality indicators
Journal
The Journal of clinical endocrinology and metabolism
Abstract
18-Hydroxy-11-deoxycorticosterone (18-OH-DOC), a normal secretory product of the human adrenal cortex, has been found to be elevated in certain forms of experimental and human hypertension. However, normal plasma levels and the acute regulatory factors for 18-OH-DOC secretion in man have not been well documented. To measure 18-OH-DOC levels in man, a specific and sensitive radio-immunoassay procedure was developed. ACTH infusion (Cortrosyn® 0.25 mg × 4 h) produced an 18–20-fold increase in mean 18-OH-DOC levels (5.8 ± 0.8 to 112 ± 12 ng %). After dexamethasone (2 mg p.o. × 2 days) mean levels fell to 0.6 ± 0.1 ng %. Diurnal variation studies under normal activity showed that 0800 h 18-OH-DOC levels (9.9 ± 1.5 ng %) fell by 60% (4.0 ± 0.8 ng %) at 1100 h and by 83% (2.7 ± 0.2 ng %) at 2300 h. To compare the relative responsiveness of 18-OH-DOC to plasma cortisol (F) and aldosterone (aldo), graded low dose infusions of ACTH (12.5-200 mIU/30 min) were performed in 6 subjects. At all infusion rates of ACTH, 1...