V. Nair, G. Buenger, T. Sells
May 30, 1991
Citations
0
Influential Citations
4
Citations
Journal
Biochimica et biophysica acta
Abstract
2',3'-Dideoxyadenosine (ddA) analogues with a variety of functionalization at the 2-position have been synthesized by a combination of thermal, photochemical and metal-mediated methodologies. These compounds are either totally resistant to deamination by mammalian adenosine deaminase (ADA) or are very poor substrates of ADA. They are competitive inhibitors of this enzyme.