J. Aufenanger, J. Pill, K. Stegmeier
Nov 1, 1985
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Horm. metabol. Res.
Abstract
BM 15.766 (4-[2-[1-(4-chlorocinnamyl)piperazin-4-yl]ethyl]benzoic acid) showed a dose dependent action on 14C-acetate incorporation in cholesterol and intermediates including squalene by adult rat hepatocytes in primary monolayer culture. The biosynthesis of cholesterol could be reduced by more than 90%. Simultaneously, the 7-dehydrocholesterol level rose in the cells and, to a less marked extent, in the culture medium.