Ivan L. Pinto, R. L. Jarvest, Brian Clarke
Feb 8, 1999
Citations
0
Influential Citations
32
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Enedione derivatives of thieno[2,3-d]oxazinones are nanomolar inhibitors of CMV protease which act through a novel dual acylation of the catalytic serine and alkylation of the protease cysteine 161 via a Michael addition to the enedione moiety of the inhibitor.