C. C. Porter, L. Watson, D. Titus
Nov 1, 1962
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Influential Citations
144
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Journal
Biochemical Pharmacology
Abstract
Abstract dl -σ-Methyl-α-hydrazino-3,4-dihydroxyphenylpropionic acid (HMD) is a potent inhibitor of DOPA decarboxylase in vitro. In vivo, the hydrazino acid inhibited the accumulation of serotonin in the kidneys of mice given 5-hydroxytryptophan (5HTP); it inhibited the urinary excretion of serotonin by 5-HTP-dosed rats; it decreased the rate of expiration of radioactive CO2 by rats which were dosed with l -1-14C-tyrosine, phenylalanine or α-methyldopa. However, it did not affect the rate of expiration of 14C-O2 by rats which were dosed with dl -l-14C-glutamic acid. HMD was concentrated by the kidneys in rats, but did not enter the brain to a measurable extent, and did not affect concentrations of endogenous serotonin in brain. It was itself decarboxylated in the rat to a greater extent after oral than after intraperitoneal administration. HMD apparently did not inhibit monoamine oxidase in vivo.