Robert L. Dixon, James R. Fouts
Aug 1, 1962
Citations
1
Influential Citations
64
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Chloramphenicol can prolong the hypnotic action of hexobarbital in mice and also slow its rate of biotransformation. Added in vitro, chloramphenicol inhibits a number of pathways for drug metabolism present in liver microsomes. Data presented indicate that this inhibition by chloramphenicol may be noncompetitive and irreversible with acetanilid and hexobarbital as substrates. These same pathways are also blocked by SKF 525-A and certain other compounds.