C. Robinson, Donald Beiergrohslein
Aug 1, 1982
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Journal of Applied Toxicology
Abstract
Methamidophos (O, S‐dimethyl phosphoramidothioate) inhibition of human erythrocyte and plasma cholinesterase was studied in vitro. The pseudo‐biomolecular rate constant of inhibition was 3.14 ± 0.22 × 103 M−1 min−1 for erythrocyte cholinesterase and 1.85 ± 0.01 × 103 M−1 min−1 for plasma cholinesterase. Thus methamidophos, although quite toxic to mammals, is a slow, rather non‐selective inhibitor of human cholinesterases, as was also observed previously in rats.