H. Skipper, R. K. Robins, J. R. Thomson
Aug 1, 1955
Citations
1
Influential Citations
42
Citations
Journal
Proceedings of the Society for Experimental Biology and Medicine
Abstract
Summary It has been demonstrated that 4-aminopyrazolo(3,4-d)pyrimidine (an isomer of adenine), and the 1-methyl derivative of this compound both significantly inhibit the growth of Adenocarcinoma 755 in mice. The former compound significantly increases the life span of mice with L1210 or L5178 leukemia. These compounds represent a new class of purine analogs with significant anticancer activity.