Melvin H. Van Woert, Steven H. Palmer
Nov 1, 1969
Citations
1
Influential Citations
56
Citations
Quality indicators
Journal
Cancer research
Abstract
The effects of three phenothiazines, chlorpromazine (CPZ), chlorpromazine sulfoxide (CPZ-O), and 7-hydroxychlorpromazine (7-OH-CPZ), on the growth of B-16 and Harding-Passey mouse melanomas were investigated. CPZ and 7-OH-CPZ both inhibited tumor growth, but CPZ-O did not. The melanoma tyrosinase was activated by CPZ both in vivo and in vitro . There was no significant effect of CPZ on the succinic oxidase and reduced nicotinamide adenine dinucleotide oxidase of either the melanoma or liver of these animals. The marked affinity of phenothiazines for melanin might be used to develop more effective melanoma chemotherapeutic agents.