K. Morita, H. Shimakawa
Dec 21, 1992
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Influential Citations
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Quality indicators
Journal
Japanese Journal of Hospital Pharmacy
Abstract
The inhibitory effects of mexiletine hydrochloride(MEX),an antiarrhythmic agent,on a monooxygenase system in mouse hepatic microsomes were studied.In vitro,MEX inhibited aniline hydroxylase and aminopyrine N-demethylase activities.The modes of inhibitions of these enzymes by MEX(mixed type)were similar to those cimetidine,while there was a great difference between inhibition constants(Ki) of MEX for aniline hydroxylase(0.05mM)and aminopyrine N-demethylase(1.26mM),in contrast to cimetidine which has a close similarity between K,values of these enzymes.The effects of MEX on the stereospecific hydroxylations of testosterone were also measured.MEX exhibited the inhibitory activities