J. G. Spivack, W. Prusoff, T. Tritton
Jul 1, 1982
Citations
0
Influential Citations
3
Citations
Journal
Antimicrobial Agents and Chemotherapy
Abstract
Methyl daunosamine inhibited the replication of herpes simplex virus type 1 in a dose-dependent manner. The growth of the host Vero cells was not affected by daunosamine levels that had significant antiviral activity (2.5 mM) but was inhibited by concentrations of 5 mM or greater. Methyl daunosamine appears to be unique among the sugars with antiviral activity because at antiviral concentrations it did not inhibit the glycosylation of macromolecules.