B. Loddo, W. Ferrari, Giovanni Brotzu
Jan 6, 1962
Citations
1
Influential Citations
61
Citations
Journal
Nature
Abstract
THE presence of a guanidine moiety in a number of antiviral drugs1–5 prompted us to investigate whether some simple guanidine derivatives may reduce the infectivity of viruses for cultured mammalian cells. The following compounds were examined: guanidine hydrochloride, aminoguanidine bicarbonate, creatine hydrate, arginine, uridine, urea, thiourea, decyl- and dodecyl-bis-guanidine, N,N′-bis(beta-hydroxyethyl)biguanide. The chemicals dissolved in water were boiled for about 15 min. and then added to the culture media.