N. Carayol, Louis Crampette, B. Mainprice
May 1, 1996
Citations
0
Influential Citations
39
Citations
Quality indicators
Journal
Allergy
Abstract
Background Mizolastine is a potent and selective H1‐receptor antagonist with antiallergic properties; in in‐vitro animal models, mizolastine was shown to inhibit 5‐lipoxygenase activity and to decrease the release of leukotrienes (LT) and tumor necrosis factor‐α (TNF‐α). This study investigated the effects of three concentrations of mizolastine (0.1, 1.0, 10 µM) on the release of LT (LTB4 and LTC4/D4) and prostaglandin D2 (PGD2) after stimulation by anti‐IgE, and on the spontaneous release of cytokines (TNF‐α and granulocyte/macrophage‐colony‐stimulating factor [GM‐CSF]), from dispersed cells obtained from surgically resected nasal polyps of patients with nasal polyposis.