F. Comelli, G. Giagnoni, Isabella Bettoni
Nov 1, 2007
Citations
5
Influential Citations
96
Citations
Quality indicators
Journal
British Journal of Pharmacology
Abstract
2‐arachidonoylglycerol (2‐AG) is an endocannabinoid whose hydrolysis is predominantly catalysed by the enzyme monoacylglycerol lipase (MAGL). The development of MAGL inhibitors could offer an opportunity to investigate the anti‐inflammatory and anti‐nociceptive role of 2‐AG, which have not yet been elucidated. On these bases, URB602, a MAGL inhibitor, was tested in a murine model of inflammation/inflammatory pain.