O. Obajimi, J. Keen, P. Melera
Aug 1, 2009
Citations
0
Influential Citations
13
Citations
Quality indicators
Journal
The Prostate
Abstract
4‐[2‐(2‐Amino‐4‐oxo‐4,6,7,8‐tetrahydro‐3H‐pyrimidino[5,4,6][1,4]thiazin‐6‐yl)‐(S)‐ethyl]‐2,5‐thienoylamino‐l‐glutamic acid (AG2034), is a classical antifolate shown to be an excellent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), ultimately inhibiting de novo purine synthesis. We examined some metabolic effects of this drug in prostate cancer cells, LNCaP, versus non‐tumorigenic prostatic epithelial cells, RWPE‐1.