F. Tietze, I. M. Klotz
Feb 1, 1952
Citations
0
Influential Citations
10
Citations
Journal
Archives of biochemistry and biophysics
Abstract
Summary Methionic and 1,2-ethanedisulfonic acids, analogs of malonic and succinic acids, respectively, inhibit the oxidation of succinate. Arsonoacetic and β-phosphonopropionic acids, however, exert no inhibitory action. Other analogs containing rings which fix the spatial orientation of the carboxyl groups ( cis - and trans -1,2-cyclopentanedicarboxylic acids, 1,1-cyclobutanedicarboxylic acid, phthalic acid, and o -sulfoben-zoic acid) show inhibitory properties, but they cannot be sufficiently differentiated in their effects to establish the configuration of the enzyme-substrate complex.