R. Hattori, R. Inoue, K. Sase
Apr 15, 1994
Citations
3
Influential Citations
62
Citations
Journal
European journal of pharmacology
Abstract
Ebselen, 2-phenyl-1,2-benzisoselenazole-3(2H)-one can preferentially inhibit the activity of inducible nitric oxide (NO) synthase with little inhibition of endothelial constitutive NO synthase within a certain concentration range. This suggests that ebselen deserves further in vivo studies to examine its possible application to the therapy of septic shock where inducible NO synthase is responsible for vasodilation.