R. W. Wrenn, N. Katoh, R. Schatzman
Aug 17, 1981
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Quality indicators
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Life sciences
Abstract
Abstract Phospholipid-sensitive and calmodulin-sensitive Ca 2+ -dependent phosphorylation of a number of endogenous proteins in the soluble and particulate fractions of the rat cerebral cortex was inhibited by phenothiazine antipsychotic drugs. The mean IC 50 values (concentrations causing 50% inhibition of phosphorylation) for trifluoperazine, chlorpromazine and fluphenazine were 16, 24 and 27 μM, respectively. Dibucaine, a local anesthetic drug, was much less effective. It appears that these neuroleptic agents may be useful tools for the study of Ca 2+ -dependent protein phosphorylating systems regulated by either phospholipid or calmodulin in the brain.