M. Imoto, T. Yamashita, T. Sawa
Mar 28, 1988
Citations
0
Influential Citations
46
Citations
Journal
FEBS Letters
Abstract
Psi‐tectorigenin, an isoflavonoid, was isolated from a culture filtrate of actinomycetes as an inhibitor of epidermal growth factor‐induced phosphatidylinositol turnover in cultured A431 cells. It inhibited phosphatidylinositol turnover with an IC50 of about 1 μg/ml; thus, its inhibitory activity was 6‐times stronger than that of genistein or orobol. When added to cultured A431 cells psi‐tectorigenin inhibited phosphatidylinositol turnover without inhibiting epidermal growth factor receptor tyrosine protein kinase. Thus, psi‐tectorigenin is a specific inhibitor of phosphatidylinositol turnover and may be a useful tool for the functional analysis of phosphatidylinositol turnover.