C. Sekido, N. Nishimura, M. Takai
Nov 23, 2010
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0
Influential Citations
10
Citations
Journal
Bioscience, Biotechnology, and Biochemistry
Abstract
Plasma hyaluronan-binding protein (PHBP) is a serine protease implicated in proteolysis under inflammatory conditions. We identified laccaic acid, a widely used food coloring from scale insects, as a potent inhibitor of the protease in terms of both autoactivation of the PHBP proenzyme (IC50 = 0.35–0.55 μg/ml) and the catalytic activity of the active enzyme (IC50 = 1.1 μg/ml).