A. Kadowaki, N. Sada, N. Juge
May 1, 2017
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Epilepsia
Abstract
The ketogenic diet is clinically used to treat drug‐resistant epilepsy. The diet treatment markedly increases ketone bodies (acetoacetate and β‐hydroxybutyrate), which work as energy metabolites in the brain. Here, we investigated effects of acetoacetate on voltage‐dependent Ca2+ channels (VDCCs) in pyramidal cells of the hippocampus. We further explored an acetoacetate analog that inhibited VDCCs in pyramidal cells, reduced excitatory postsynaptic currents (EPSCs), and suppressed seizures in vivo.