L. Stuyver, Tamara R. Mcbrayer, Tony Whitaker
Feb 1, 2004
Citations
2
Influential Citations
62
Citations
Journal
Antimicrobial Agents and Chemotherapy
Abstract
ABSTRACT 2′-Deoxy-2′-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5′-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due to an S-phase arrest. These observations demonstrate that FdC treatment is affecting both a viral target and a cellular target.