P. Colla, M. A. Marcialis, O. Flore
May 1, 1977
Citations
0
Influential Citations
9
Citations
Journal
Annals of the New York Academy of Sciences
Abstract
Besides the well-known 5-iodo-2'-deoxyuridine (IUdR) and cytosine arabinoside (ara-C), today in clinical use,' other pyrimidine derivatives have been found endowed with antiviral a c t i ~ i t y . ~ ~ Among them, dichloropyrimidines are of interest both for their antiviral spectrum and mode of action. Dichloropyrimidines inhibit the growth of unrelated R N A and DNA viruses, such as polio 1, coxsackie BI, vaccinia and herpes simplex viruses, while being inactive against vesicular stomatitis virus and Newcastle disease virus. As shown for the most active of these compounds, 2-amino4,6-dichloropyrimidine, these compounds prevent assembly of virus particles by acting on structural virus proteins.