K. Takagi, I. Takayanagi, T. Irikura
Jun 1, 1969
Citations
0
Influential Citations
6
Citations
Journal
Japanese journal of pharmacology
Abstract
During works on anti-5-hydroxytryptamine activity of tryptamine derivatives, 3 (2'-benzylaminoethyl)-5-methoxyindol hydrochloride (S-8) of which a chemical structure is shown in Chart 1 has been found to be a potent competitive inhibitor of 5-hydroxytrypt amine (HT) action on the fundus of the isolated rat stomach, the isolated guinea pig uterus and the isolated guinea pig taenia caecum (taenia coli). It has been also found that S-8 depresses a rise of blood pressure of the rat caused by HT.