S. Udenfriend, P. Zaltzman-Nirenberg, Toshiharu Nagatsu
May 1, 1965
Citations
6
Influential Citations
317
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Two classes of compounds have been investigated as inhibitors of purified beef adrenal tyrosine hydroxylase. Among the aromatic amino acids tyrosine analogues were found to be most potent, particularly those having an α-methyl or 3-halogen substitution. Two normal metabolites, mono- and diiodo-tyrosine, were found to be very effective inhibitors. Inhibition by the amino acid analogues was shown to be competitive with the substrate. Catechols were also inhibitory, particularly 3,4-dihydroxy-phenylpropylacetamide (compound H 22/54). Inhibition by the latter was reversed by cofactor (tetrahydrofolate or DMPH 4 ) but not by tyrosine.