Li Yun-man, K. Kai, Fang Wei-rong
2006
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Quality indicators
Journal
Chinese Journal of Clinical Pharmacology and Therapeutics
Abstract
AIM: To study the effect of Lomerizine on the activity of P-glycoprotein (P-gp) in the blood-brain barrier(BBB) and search for novel effective P-gp inhibiting agent against multidrug resistance. METHODS: Rhodamine123 (Rh123) was used to examine the activity of P-gp and RT-PCR to study the mdr mRNA expression in cultured rat brain microvessel endothelial cells (RBMECs). RESULTS: Lomerizine could increase the cellular Rh123 in RBMECs in a concentration-dependent manner. RT-PCR indicated that lomerizine could not down-regulate the expression of mdr mRNA. CONCLUSION: Lomerizine can reverse multidrug resistance in the blood-brain barrier by inhibiting the activity of P-gp.