I. Berenblum, N. Haran
Sep 1, 1955
Citations
0
Influential Citations
27
Citations
Journal
British Journal of Cancer
Abstract
ETHYL carbamate (urethane) was shown by Salaman and Roe (1953) to act as an initiating agent for carcinogenesis, causing mouse skin to become responsive to subsequent croton oil treatment. (The carcinogenic effect of alternate applications of urethane and croton oil to mouse skin, representing a dual co-carcinogenic action by these two agents, was independently demonstrated by Graffi, Vlamynck, Hoffmann, and Schulz (1953) and by Salaman and Roe (1953). According to both groups, urethane alone is non-carcinogenic for mouse skin.) The present investigation was undertaken to confirm the initiating action of urethane and to gain more information about the number of applications required for this effect to be obtained. Mfeanwhile, a second communication by Roe and Salaman (1954) appeared, which partly covers the same field.