G. Schrauzer
1978
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Influential Citations
68
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Abstract
Platinum coordination complexes form a new class of active anticancer agents in animals and man. Cis-dichlorodiarnrnineplatinum(II), the most widely investigated drug, is now in experimental clinical use against a wide variety of cancers in man. The dose-limiting toxicity in man is renal tubular damage. Hydration of the patient and the use of osmotic diuretics have minimized this effect and allowed higher doses with largely improved responses. Combination chemotherapy with the drug has also produced significant response rates in a variety of cancers. The mode of action of the drug is not yet clear, but most likely involves a primary lesion on nuclear DNA and the stimulation of a host reaction to the cancer. So far, only square planar and octahedral complexes of platinum, with a variety of inorganic and organic ligands, have shown marked activity in animal studies. * This manuscript is, in large part, taken from a review paper that appeared in Die Naturwissenschaften 60, Pages 399-406, in 1973. New sections and some revisions:have been made, updating the data.