Aastha Pareek and Dharma Kishor
2015
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Journal
International journal of pharma and bio sciences
Abstract
A quinoxaline, also called a benzopyrazine, in organic chemistry, is a heterocyclic compound containing a ring complex made up of a benzene ring and a pyrazine ring. It is isomeric withother naphthyridines including quinazoline, phthalazine and cinnoline.Quinoxa lines are used as dyes, pharmaceuticals and antibiotics such as echinomycin,levomycin and actinoleutin.Some studies were carried out in order to explore the antitumoral properties of quinoxaline compounds: Recently, quinoxaline and its analogs have been investigated as the catalyst's ligands: They can be formed by condensing ortho-diamines with 1,2-diketones. The parent substance of the group, quinoxaline, results when glyoxal iscondensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones. Quinoxaline and its analogues may also be form by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB):