D. Karati, K. Mahadik, P. Trivedi
Mar 3, 2022
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Influential Citations
4
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Quality indicators
Journal
Medicinal chemistry (Shariqah (United Arab Emirates))
Abstract
BACKGROUND Pyrazole is a bioactive heterocyclic congener found in a wide range of biological and pharmacological applications. Due to their multiple prospective uses, developing innovative pyrazoles and analogues, disclosing revolutionary ways for synthesizing this nucleus, investigating diverse potencies of that heterocycle, and seeking for possible applications of pyrazoles are all growing more significant Objectives: Pyrazole scaffolds have been proven to be successful as antimicrobial, anticancer, antimalarial therapeutic against multiple targets like DNA gyrase, topoisomerase IV, Hsp90, and several kinase enzymes. Its moiety has absorbed the attention of many scientists to research chemical and pharmacological profile due to this miscellany in the biotic region. RESULTS The review covers pyrazole scaffolds with a variety of biological functions, as well as attempts to connect the structure-activity relationship. Multiple pyrazole analogues have been produced as lead compounds, and their activities have been evaluated. CONCLUSION The combination of pyrazole with other pharmacophores in a molecule might lead to novel potent therapeutic medicines, which could aid in the development of potent lead compounds.