G. Yadav, Gunjan P. Deshmukh
Nov 1, 2017
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0
Influential Citations
2
Citations
Journal
Journal of Chemical Sciences
Abstract
Abstract2-Methyl-4-chlorophenoxy propionic acid (Mecoprop) is a widely used household herbicide. In the current work, a simple synthetic method is developed for Mecoprop methyl ester using solid-liquid phase transfer catalysis (S-L PTC) with $$\hbox {K}_{2}\hbox {CO}_{3}$$K2CO3 as mild base and toluene as solvent. Conversion of 95% was achieved with 100% selectivity for Mecoprop ester at $$100\,{^{\circ }}\hbox {C}$$100∘C. Simple isolation process was employed to recover the product from the reaction mixture. A reaction mechanism was proposed and new kinetic model developed involving one liquid and two solid co-products. The activation energy for the reaction was calculated. This is the first example of its kind being reported vis-à-vis kinetics and mechanism.Graphical AbstractSolid-liquid phase transfer catalyzed (S-L PTC) O-alkylation of 4-chloro-2-methyl phenol is done at relatively mild conditions to form methyl 2-(4-chloro-2-methylphenoxy) propionate (Mecoprop methyl ester). New insight on reaction mechanism and kinetics is presented.