Florian Biba, M. Groessl, Alexander E Egger
Oct 1, 2009
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0
Influential Citations
35
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Journal
European Journal of Inorganic Chemistry
Abstract
The lanthanide complex tris(1,10-phenanthroline)tris(thiocyanato-κN)lanthanum(III) [La(phen)3(NCS)3] (KP772) is a promising anticancer drug candidate, capable of overcoming resistance of tumors to established chemotherapeutics. The compound was characterized by elemental analysis, IR, 1H NMR spectroscopy, TG/DTA measurements, mass spectrometry and X-ray diffraction analysis. The results indicate that KP772 is a neutral, nine-coordinate complex. In addition the behavior in water, important for the application as a chemotherapeutic drug, and the binding to biomolecules was investigated by capillary electrophoresis and ICP-MS.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)