Alexandra Teodora Bordei Telehoiu
Jun 28, 2021
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Quality indicators
Journal
FARMACIA
Abstract
According to recent research, both carbazol and 1,3,4-oxadiazol derivatives are known for their antioxidant properties. The aim of our research was the evaluation of antioxidant activity and in vivo cytotoxicity of some new heterocyclic compounds, which both contain pharmacophore groups. The antioxidant activity was evaluated by means of scavenger activity towards 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) free radicals. In vivo cytotoxicity was assessed using Artemia franciscana nauplii lethality bioassay. Our results have shown that the analysed compounds can be further used for their antioxidant capacity. For the analysed concentration interval (25 1000 μM), the scavenger capacity towards ABTS free radical was higher compared to the DPPH assay. All tested compounds showed an adequate safety profile. Further research is needed for evaluation of in vivo antioxidant effects of tested compounds and furthermore their safety via pre-clinical tests.