Fengcheng Jia, Cheng Xu, Qun Cai
Jul 31, 2014
Citations
0
Influential Citations
16
Citations
Journal
Chemical communications
Abstract
A highly efficient three-component domino protocol has been developed for the synthesis of [1,2,4]triazolo[1,5-b]isoquinolin-5(1H)-ones from simple and readily available o-halogenated benzohydrazides, aldehydes and nitriles. This domino process involves sequential selective condensation, copper-catalyzed intermolecular C-arylation and bicyclization. Notably, the use of ligands and anaerobic conditions can be avoided in this reaction.