K. Sunaga, T. Imamura, S. Koide
Jun 9, 1970
Citations
0
Influential Citations
6
Citations
Journal
Biochimica et biophysica acta
Abstract
Abstract The characteristics of the reaction of 11β,17α-dihydroxy-2,4-pregnadiene 3,20-dione-21-al (21-dehydroprednisolone) with amino acids under varying conditions were investigated. The rate of the reaction of 21-dehydroprednisolone with alanine was accelerated with increasing concentration of reactants, at alkaline pH, with elevation of temperature and in the presence of phosphates. The products of the reactions were steroid-amino acid complexes (Schiff bases), 21-amino or 21-imino corticosteroid derivatives and keto acids. The 21-amino- or 21-imino-prednisolone may react with excess 21-dehydroprednisolone to form a diprednisolone amine.