R. Pyttel, J. B. Robinson
Apr 1, 1973
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
The preparation of R-(−)-3-quinuclidinol and its acetate ester is reported. These compounds, together with their racemates, were tested as inhibitors and substrates of the enzyme acetylcholinesterase. The results suggest that the enzyme active site is stereospecific toward R-(−)-3-quinuclidinol hydrochloride when acting as an inhibitor. Both (±)- and R-(−)-3-acetoxyquinuclidine hydrochloride are substrates of the enzyme, but the S-enantiomer probably has some affinity for the enzyme also.