D. Coult, R. G. Wilkinson
May 1, 1977
Citations
0
Influential Citations
8
Citations
Journal
Biochemical pharmacology
Abstract
Abstract 4-Alkyl-2,6,7-trioxa-1-phosphabicyclo [2,2,2] octanes are weak competitive inhibitors of the high- K m form of cyclic adenosine 3′,5′-monophosphate phosphodiesterase (PDE) and non-competitive inhibitors of the low- K m form enzyme. The possibility that inhibition of the low- K m form enzyme by the bicyclic organo-phosphates may contribute to their toxic action is discussed. The compounds do not affect the binding of adenosine 3′,5′-monophosphate (cyclic AMP) with specific binding proteins, and are unlikely to have any effect on cyclic AMP receptors.