С. А. Чумаченко, О. В. Шаблыкин, В. С. Броварец
Dec 4, 2014
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Chemistry of Heterocyclic Compounds
Abstract
5-Morpholino-1,3-oxazole-4-carbonitriles containing a 4-phthalimidobutyl or 5-phthalimidopentyl substituent at position 2 of the oxazole ring were synthesized. In the reaction of 5-(morpholin-4-yl)-2-(4-phthalimidobutyl)-1,3-oxazole-4-carbonitrile with hydrazine hydrate, the recyclization product (3-amino-5,6,7,8-tetrahydroimidazo[1,2-а]pyridin-2-yl)(morpholin-4-yl)methanone is formed. In the case of 5-(morpholin-4-yl)-2-(5-phthalimidopentyl)-1,3-oxazole-4-carbonitrile, after removing of protection phthalimide group, the reaction stopped at stage of 2-(5-aminopentyl)-5-(morpholin-4-yl)-1,3-oxazole-4-carbonitrile formation. How to Cite Chumachenko, S. A.; Shablykin, O. V.; Brovarets, V. S . Chem. Heterocycl. Compd. 201 5 , 50 , 1727. [ Khim. Geterotsikl. Soedin. 2015 , 1877.] For this article in the English edition see DOI 10.1007/s10593-015-1644-2