S. M. Blaug, A. G. Rich
1965
Citations
0
Influential Citations
11
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
The interaction between certain pharmaceuticals and poly- N -vinyl-5-methyl-2-oxazolidinone is reported. Compounds studied include aromatic hydroxyl compounds, aromatic amino compounds, p -hydroxybenzoic acid esters, barbiturates, plant growth hormones, and sulfonamides. A dialysis method is used to study the complexing reaction. Data indicate that, in general, p -substituted compounds exhibit a degree of binding greater than their m -isomers. The o -substituted compounds appear to interact less than the p - or m -substituted compounds with poly- N -vinyl-5-methyl-2-oxazolidinone. 5,5-Substitution of barbituric acid greatly reduces its ability to associate with the polymer. Data are reported to show the value K , the ratio of the total drug concentration in solution to the concentration of the unbound drug as a function of the polymer concentration.