V. Magafa, G. Stavropoulos, P. Tsiveriotis
May 1, 1998
Citations
0
Influential Citations
11
Citations
Journal
Inorganica Chimica Acta
Abstract
Abstract The mercury(II) complexes [(Boc-Cys-Ser-Ala-Cys-NH 2 ) 2 Hg 2 Cl]Na·4H 2 O ( 1 ), (Boc-Cys-Ser(Bzl)-Ala-Cys-NH 2 ) 2 Hg 3 Cl 2 ( 2 ), (Boc-Cys-Ser(Bzl)-Ala-Cys-NH 2 )Hg 2 Cl 2 ( 3 ), [(Boc-Cys-Gly-Ala-Cys-NH 2 ) 2 Hg 2 Cl]Na·3H 2 O ( 4 ), (Boc-Cys-Gly-Ala-Cys-OCH 3 ) 2 Hg 4 Cl 2 ·2H 2 O ( 5 ), (Boc-Cys-Gly-Ala-Cys-OCH 3 )Hg 2 Cl 2 ·2H 2 O ( 6 ), (Boc-His-Ser(Bzl)-Ala-Cys-NH 2 )Hg 2 Cl 2 ( 7 ) and [(Boc-His-Ser(Bzl)-Ala-Cys-NH 2 )Hg 2 Cl 2 ]Cl ( 8 ) were synthesized from HgCl 2 and the corresponding free or S -acetamidomethyl (Acm) and N un -Boc protected peptides, by different synthetic routes, Acm and N un -Boc protecting groups are removed upon mercury(II) coordination, while the Bzl group was removed selectively prior to reactions of the peptides with mercury(II). The peptides and the complexes formed were characterized by elemental analysis, conductivity measurements, IR, UV, and 1D and 2D 1 H and 13 C NMR spectroscopies. In addition, 199 Hg NMR experiments suggest that mercury(II) ions exchange rapidly between chloride ions and imidazole nitrogens. Conformational studies of the peptides in the complexes formed, by ROESY experiments, suggested macromolecular chelate structures with mercury(II).