R. Werner, W. Reuter
1979
Citations
0
Influential Citations
8
Citations
Quality indicators
Journal
Arzneimittel-Forschung
Abstract
When compared with other tryptophan analogues, indolmycin is a potent inhibitor of tryptophan pyrrolase and tryptophan decarboxylase, both enzymes involved in tryptophan catabolism. Otherwise the decarboxylation of 5-hydroxytryptophan is only slightly affected by indolmycin. The indolmycin derivative, 2-methylamino-5-(1-naphthylmethyl)-oxazolidin-4-one (YX-CX 22 XX) demonstrates only a slightly weaker inhibitory effect in the tryptophan-tRNA-ligase system in E. coli but does not show any significant action on the tryptophan metabolism in the eukaryotic system.