V. I. Pol'shakov, Y. Sheinker
2004
Citations
0
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Journal
Pharmaceutical Chemistry Journal
Abstract
Among the drugs currently being used in the clinical chemotherapy of cancer, an important place is occupied by derivatives of dispirotripiperazinium (3,12-diaza-6,9-diazoniadispiro[5,2,5,2]hexadecane dichloride) prospidine (II) and spirobromine (III). The original member of this group of drugs, spirazidine (I), also proved effective in the treatment of a number of forms of malignant neoplasms [9]; however, it was subsequently removed from commercial manufacture in view of its low stability in aqueous solutions and thehigh toxicity of one of the intermediates in the synthesis of I [2].