S. Dennison, T. Snape, D. Phoenix
Jul 11, 2012
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Influential Citations
12
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Quality indicators
Journal
European Biophysics Journal
Abstract
The activity of a membrane interactive cis and trans benzanilide against Escherichia coli membrane mimics was investigated using Langmuir monolayers. It was found that in the presence of E. coli lipid mix monolayers, cis-benzanilide induced maximal surface pressure changes of 1 mN m−1, whereas a reduced interaction was observed with trans-benzanilide. Compression isotherm analysis of these monolayers showed ∆Gmix < 0, indicating membrane stabilisation by both compounds. The binding coefficient for trans-benzanilide was circa 890 μM and for the cis-benzanilide was 820 μM, suggesting that both benzanilide compounds bound to the E. coli membranes.