M. Givskov, R. Nys, M. Manefield
Nov 1, 1996
Citations
23
Influential Citations
757
Citations
Quality indicators
Journal
Journal of Bacteriology
Abstract
Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.