Zhi-Xiong Deng, Zhenzhen Xie, Yu Zheng
Feb 20, 2019
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Influential Citations
5
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Journal
Organic & biomolecular chemistry
Abstract
A new strategy for the synthesis of functionalized tetrahydrofuran derivatives was developed via a phosphine-catalysed [3 + 2] cyclization reaction of aromatic aldehydes with 4-phenylbut-3-yn-2-one. This is the first example of intermolecular cyclization of ynones with benzaldehydes, which essentially benefited from the intramolecular hydrogen bonding. This new protocol features a broad substrate scope, mild reaction conditions, operational simplicity and easy scale-up.