Yuriko Akiyama, C. Hiramatsu, Tsuyoshi Fukuhara
Jul 1, 2006
Citations
0
Influential Citations
18
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract Ring-opening fluorination reactions of epoxides using tetrabutylammonium bifluoride (TBABF)-KHF 2 , or Et 3 N-3HF under microwave irradiation were applied for the introduction of a fluorine atom into the carbohydrate molecules. When TBABF-KHF 2 was used as the fluorination reagent, a fluorine atom was introduced regioselectively and various functional groups can tolerate the conditions. When Et 3 N-3HF was used under microwave irradiation, the reaction time could be remarkably shortened compared with the conventional oil-bath heating.