Morgan Donnard, Guillaume Duret, P. Bisseret
Jun 1, 2017
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0
Influential Citations
3
Citations
Journal
Comptes Rendus Chimie
Abstract
Abstract Three representative 6,7-dihydro-5 H -cyclopenta[ b ]pyridin-4-amines were synthesized using an intramolecular inverse electron demand hetero–Diels–Alder/retro–Diels–Alder sequence between pyrimidines (acting as azadienes) and ynamides (acting as dienophiles). Two solvents of this reaction, sulfolane and trifluorotoluene, were compared at 210 °C and the former consistently led to higher yields. In addition, these studies confirmed the importance of the steric bulk of the C5-position of the pyrimidinyl cycloaddition precursor.